So people here is next week’s paper for discussion.

Microanatomy at Cellular Resolution and Spatial Order of Physiological Differentiation in a Bacterial Biofilm

I had a hard choice and I have decided on one of two stories (the other one was on phages) that caught my attention at the BACNET13 meeting I attended in Poland recently.

The wonderful images produced by the Hengge lab while dissecting the role of c-di-GMP in biofilm formation won. You will need to use the online material as well as the paper for this one.

We have discussed c-di-GMP and Biofilms sometime back and it is a subject that started my own journey into the fascinating world of Caulobacter crescentus as a young Post-Doc. Regine Hengge gave an excellent talk on this story at BACNET. The field of c-di-GMP itself played a central role at this meeting. What was clear to me is that the field has begun to move on from the biochemical characterisation of the components involved to returning to the underlying question of what c-di-GMP is regulating, why and how? Clearly exciting times are ahead for the field.

As per usual our discussion will focus on:

1) Did the paper read well?

2) Could you understand the regulatory network?

3) Would you have done anything differently?

4) where next?

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