Hi all!

I have chosen this paper, because I think it is an interesting topic and also because we have not had anything on Streptomyces yet. Furthermore since this work, is from a former student of my supervisor, and she is willing to attend the session and so will Paul. So we get some input from the researcher directly! 

Hopefully see many of you on the 2nd of April at 8 pm BST! 

Here it goes: http://www.nature.com/srep/2013/130123/srep01109/full/srep01109.html

Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence

This week’s Journal Club is on a publication on how virulence might have evolved in bacteria. The non-pathogenic soil bacterium S. coelicolor, nevertheless in their genome you can find homologues of virulence loci. This paper investigates the mammalian cell entry locus (mce) in S. coelicolor, it has previously been characterised in M. tuberculosis. The study investigates its impact on cell survival, morphology and interaction with other soil organisms (A. polyphaga and Arabidopsis). The results suggest that the genes play an important role in survival in the environment and give hints into the evolution and selection as these genes as virulence factors.

Discussion points:

–          Was the publication easy to read/follow/understand?

–          Do you think this research is helping to understand how virulence evolved?

–          Which follow up experiments could be done based on the data presented?